My first computer was a Commodore 64, and I've never really liked the mouse. I do chuckle along with some people when I explain emacs commands, but I love 'em! (Although, a quick aside, I think that when I am using a mouse, I'd actually like one for each hand. And I love the idea that the joystick was initially intended to be a productivity tool. I have no idea why it failed where the mouse succeeded.)
Anyway, here's an interesting article, courtesy of itworld.com via slashdot.org, about 7 days without a mouse.